This app uses a self-consistent method to translate amino acid
sequences into audible sound. The sonification method uses the
normal mode vibrations of the amino acid building blocks of
proteins to compute an audible representation of each of the 20
natural amino acids which is fully defined by the overlay of its
respective natural vibrations. The vibrational frequencies are
transposed to the audible spectrum following the musical concept of
transpositional equivalence playing or writing music in a way that
makes it sound higher or lower in pitch while retaining the
relationships between tones or chords played. This transposition
method ensures that the relative values of the vibrational
frequencies within each amino acid and amongst different amino
acids are retained.
The characteristic frequency spectrum and sound associated with each of the amino acids represents a type of musical scale that consists of 20 unique tones the amino acid scale. To create a playable instrument each tone associated with the amino acids is assigned to a specific key on the screen of your phone which can be played. The app allows users to record sequences that were played edit them and share them for further processing (e.g. creating synthetic proteins based on the music composed or predicting the folded structure of a sequence created through music).
The approach of creating audio representations of protein sequences offers a new avenue for understanding sequence patterns variations and mutations and offers an outreach mechanism to explain the significance of protein sequences. The method reported here also offers insight into the effect of mutations through sound.
Scientific publication:
[1] Yu C. H. Qin Z. Martin-Martinez F. and Buehler M. J. A self-consistent sonification method to translate amino acid sequences into musical compositions and application in protein design using AI in submission.
App developed by Eric L. Buehler
The characteristic frequency spectrum and sound associated with each of the amino acids represents a type of musical scale that consists of 20 unique tones the amino acid scale. To create a playable instrument each tone associated with the amino acids is assigned to a specific key on the screen of your phone which can be played. The app allows users to record sequences that were played edit them and share them for further processing (e.g. creating synthetic proteins based on the music composed or predicting the folded structure of a sequence created through music).
The approach of creating audio representations of protein sequences offers a new avenue for understanding sequence patterns variations and mutations and offers an outreach mechanism to explain the significance of protein sequences. The method reported here also offers insight into the effect of mutations through sound.
Scientific publication:
[1] Yu C. H. Qin Z. Martin-Martinez F. and Buehler M. J. A self-consistent sonification method to translate amino acid sequences into musical compositions and application in protein design using AI in submission.
App developed by Eric L. Buehler
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